North Fort Myers is an unincorporated area and census-designated place (CDP) in Lee County, Florida, United States. The population was 42,719 at the 2020 census, up from 39,407 at the 2010 census. It is part of the Cape Coral-Fort Myers, Florida Metropolitan Statistical Area.

North Fort Myers is located in northern Lee County at 26°42′N 81°53′W / 26.700°N 81.883°W / 26.700; -81.883 (26.7029, -81.8844), northwest across the Caloosahatchee River from Fort Myers proper. It is bordered to the west by the city of Cape Coral and to the north by Charlotte County.

Interstate 75 runs through North Fort Myers, with access from Exit 143 (Florida State Road 78). I-75 leads northwest 67 miles (108 km) to the Sarasota area and south 38 miles (61 km) to the Naples area, while SR-78 leads east 34 miles (55 km) to LaBelle and west 16 miles (26 km) to Pine Island Center. U.S. Route 41 (North Tamiami Trail) passes through the center of North Fort Myers, leading southeast across the Caloosahatchee Bridge into the center of Fort Myers and northwest 24 miles (39 km) to Port Charlotte.

According to the United States Census Bureau, the North Fort Myers CDP has a total area of 54.4 square miles (140.9 km2), of which 50.6 square miles (131.1 km2) are land and 3.8 square miles (9.8 km2), or 6.97%, are water.

As of the 2020 United States census, there were 39,407 people, 20,264 households, and 10,206 families residing in the CDP.

For the period 2013–2017, the estimated median annual income for a household in the CDP was $39,876, and the median income for a family was $53,893. Male full-time workers had a median income of $41,079 versus $34,207 for females. The per capita income for the CDP was $26,891. About 9.0% of families and 13.8% of the population were below the poverty line, including 20.8% of those under age 18 and 8.3% of those age 65 or over.

As of the 2010 United States census, there were 42,719 people, 20,468 households, and 12,082 families residing in the CDP.

Of the 20,468 households in 2010, 12.2% had children under the age of 18 living with them, 49.1% were headed by married couples living together, 6.8% had a female householder with no husband present, and 40.8% were non-families. 33.9% of all households were made up of individuals, and 22.0% were someone living alone who was 65 years of age or older. The average household size was 1.98, and the average family size was 2.45.